Dee Jepsen was founding President of Enough Is Enough®, and served as its President Emeritus.

Dee was a national and international lecturer, was a frequent guest on local and national radio and television programs-speaking with a special sensitivity to the role of women. She was interviewed by many newspapers and magazines, featured in numerous books and is an award-winning author of books written to encourage women. For some years she wrote a column for her home state newspaper and hosted a weekly radio commentary, giving a behind-the-scenes view of events in Washington. Dee twice testified before the United States Senate Judicaiary Committee on the dangers posed to children by exposure to computer pornography, and the threat to them from pedophile activity on the Internet.

In the early '80's Dee served President Ronald Reagan on the President's Task Force on Private Sector Initiatives; then as a Special Assistant to the President at the White House, there serving as a liaison to women's organizations. President Reagan praised Dee's commitment to "justice, fair, dealing, and equal opportunity under our system of law."

From 1979 until 1982 Dee worked as a full-time, unsalaried assistant to her husband, former United States Senator. Roger Jepsen from Iowa. During her days on Capitol Hill, Dee was an active member of the Congressional Wives for Soviet Jewry (an organization that supported Jews who were undergoing persecution behind the Iron Curtain), and was involved in founding CREED (an organization to assist Christians being persecuted for their faith behind the Iron Curtain).

Dee formerly chaired the Regent University Board of Trustees and served on numerous boards, including on the Virginia Board of Social Services. She is also an avid artist.

Senator and Mrs. Jepsen resided in Port Charlotte, Florida, They had six children (one deceased), nine grandchildren and one great grandchild.